Mitochondrial Ca 2 + activates a cation current 1 in Aplysia bag cell neurons
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چکیده
Mitochondrial Caactivates a cation current 1 in Aplysia bag cell neurons 2 3 4 by: 5 6 7 Charlene M. Hickey, Julia E. Geiger, Chris J. Groten, and Neil S. Magoski 8 9 10 Department of Physiology, Queen’s University, Kingston, ON, K7L 3N6, Canada 11 12 13 Running title: mitochondrial Ca gates a cation current 14 15 16 Submitted to the Journal of Neurophysiology as a research article 17 18 19 Manuscript contains: pages (38), figures (10), references (96), tables (0). 20 21 22 Word count: total (8985), abstract (297; 300 limit), introduction (493), 23 methods (1674), results (2816), discussion (1831), figure legends (1874). 24 25 26
منابع مشابه
Mitochondrial Ca Activates a Cation Current in Aplysia Bag Cell Neurons
Hickey CM, Geiger JE, Groten CJ, Magoski NS. Mitochondrial Ca activates a cation current in Aplysia bag cell neurons. J Neurophysiol 103: 1543–1556, 2010. First published January 13, 2010; doi:10.1152/jn.01121.2009. Ion channels may be gated by Ca entering from the extracellular space or released from intracellular stores—typically the endoplasmic reticulum. The present study examines how Ca im...
متن کاملMitochondrial Ca2+ activates a cation current in Aplysia bag cell neurons.
Ion channels may be gated by Ca(2+) entering from the extracellular space or released from intracellular stores--typically the endoplasmic reticulum. The present study examines how Ca(2+) impacts ion channels in the bag cell neurons of Aplysia californica. These neuroendocrine cells trigger ovulation through an afterdischarge involving Ca(2+) influx from Ca(2+) channels and Ca(2+) release from ...
متن کاملActivation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.
The ability of sodium pyrithione (NaP), an agent that produces delayed neuropathy in some species, to alter neuronal physiology was accessed using ratiometric imaging of cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in fura PE-filled cultured Aplysia bag cell neurons. Bath-application of NaP evoked a [Ca(2+)](i) elevation in both somata and neurites with an EC(50) of approximately 300 nM an...
متن کاملPersistent Ca2+ current contributes to a prolonged depolarization in Aplysia bag cell neurons.
Neurons may initiate behavior or store information by translating prior activity into a lengthy change in excitability. For example, brief input to the bag cell neurons of Aplysia results in an approximate 30-min afterdischarge that induces reproduction. Similarly, momentary stimulation of cultured bag cells neurons evokes a prolonged depolarization lasting many minutes. Contributing to this is...
متن کاملFlufenamic Acid Affects Multiple Currents and Causes Intracellular Ca Release in Aplysia Bag Cell Neurons
Gardam KE, Geiger JE, Hickey CM, Hung AY, Magoski NS. Flufenamic acid affects multiple currents and causes intracellular Ca release in Aplysia bag cell neurons. J Neurophysiol 100: 38–49, 2008. First published April 24, 2008; doi:10.1152/jn.90265.2008. Flufenamic acid (FFA) is a nonsteroidal antiinflammatory agent, commonly used to block nonselective cation channels. We previously reported that...
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تاریخ انتشار 2010